Prolonged release melatonin in the treatment of primary insomnia

This study investigated the efficacy and safety of Prolonged-Release Melatonin (PRM) in elderly insomnia patients.

The study included participants aged 18-80 years and found that PRM had significant positive effects on sleep latency, sleep quality, quality of life, and overall clinical improvements in those aged 55 and over, with no signs of tolerance over the 6-month period. The study also found that PRM was well-tolerated with no rebound or withdrawal symptoms.

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